Study of Azone in Percutaneous Permeation of Compound Tinidazole Gel
- VernacularTitle:氮酮促进复方替硝唑凝胶经皮渗透作用研究
- Author:
Yongjun ZHANG
;
Zhigeng YU
;
Zhilin HU
- Publication Type:Journal Article
- Keywords:
compound tinidazole gel;
azone;
percutaneous absorption;
RP-HPLC
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the enhancing effects of azone at different concentrations on percutaneous permeation of compound tinidazole gel and to find out the best concentration.METHODS:Using vertical Franz-type diffusion cell and dif?ferent concentrations of azone as enhancer,the concentrations of tinidazole,chloramphenicol and salicylic acid in permeation solution were measured by RP-HPLC,then cumulative permeation quantity(Q)was calculated.RESULTS&CONCLUSION:Azone at different concentrations could promote the permeability of3ingredients of compound tinidazole gel,and2%azone had the most obvious permeation-enhancing effect.
