Preparation of Diclofenac Sodium Controlled Release Pellets and Study on the Release Behaviour
- VernacularTitle:双氯灭痛控释微丸的制备与释药的研究
- Author:
Dayi JIANG
;
Dee NING
;
Chun DONG
;
Cui CHANG
;
Hongtu YANG
;
Mengliang JIA
- Publication Type:Journal Article
- Keywords:
diclofenac sodium;
controlled release pellets;
release mechanism
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare diclofenac sodium controlled release pellets and investigate the mechanism of re?lease.METHODS:Single-factor method was used to investigate the influence of the composition of solvent system in coating solution,the concentration of coating material,porogenic agent and plastifier on the release rate of drug.RESULTS:When the concentration of coating material and the proportion of water increased,the release rate of pellets was increased;the release rate was further increased with PVP K30 added.CONCLUSION:The pellets belongs to the matrix-coating pellets,and the release mechanism varies with the change of coating thickness.
