Effect of adenovirus-mediated myoglobin gene expression in decreasing hepatic ischemia reperfusion injury
- VernacularTitle:肌红蛋白的表达对肝缺血再灌注损伤的保护作用
- Author:
Xundi XU
;
Shengfu HUANG
;
Jixiong HU
;
Qinglong LI
;
Leping YANG
;
Qunwei WANG
;
Guoli LIU
;
Zhulin YANG
;
Yongguo LI
;
Dewu ZHONG
;
Xiongying MIAO
- Publication Type:Journal Article
- Keywords:
HEPATIC ISCHEMIA REPERFUSION INJURY/prev;
MYOGLOBIN/ther use;
LIVER/metal
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of expression of myoglobin which mediated by adenovirus,on ATP value of liver and the protective effect on liver ischemia reperfusion injury.Methods Adenovirus carrying CMV promoter sequences linked to the human myoglobin gene(AdCMVMyo) were transfected into rats liver. Then myoglobin, hepatic ATP levels and liver function were evaluated. Results Myoglobin expression was verified in rat livers after AdCMVMyo transfection. The ATP levels in rat livers 72 hours after AdCMVMyo transfection were significantly higher than that in control group(P
