A new acute pancreatitis mice model
- VernacularTitle:一种新的小鼠急性胰腺炎动物模型
- Author:
Zhijun HE
;
Haizhi QI
;
Xiongying MIAO
- Publication Type:Journal Article
- Keywords:
PANCREATITIS;
DISEASE MODELS,ANIMAL
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a new severe but sublethal acute pancreatitis mice model. Methods The animals were divided into two groups: the bile acid injection group and the control group. In the bile acid injection group, acute necrotizing pancreatitis was induced by intraductal administration of 0.1 ml of 1.0 % bile acid under 30 cm H 2O pressure, while the controls underwent the sham operation. The structural and functional features of the pancreas were examined at 24 hours after surgery. Results Pancreatic edema, bleeding, acinar cell necrosis and inflammation accompanied with increased serum amylase and MPO were found in the bile acid injection animals. Conclusions The sublethal acute pancreatitis mice model is ideal for pathogenetic and therapeutic study of acute necrotizing pancreatitis.
