Effect of experimental acute necrotizing pancreatitis on sodium and L-type calcium current in rat cardiomyocytes
- VernacularTitle:急性坏死性胰腺炎对心室肌细胞钠和钙离子电流的影响
- Author:
Chao DING
;
Liye HU
;
Shuying QI
;
Li YANG
;
Qiao SHI
;
Xiaoyun LIU
;
Junyu CUI
;
Zhenshan HE
- Publication Type:Journal Article
- Keywords:
Pancreatitis, acute necrotizing;
Sodium channels;
Calcium channels;
Myocardium;
Rats
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of experimental acute necrotizing pancreatitis (ANP) on sodium and L-type calcium current in rat cardiomyocytes. METHODS: I Na and I Ca-L were recorded using whole cell patch-clamp techniques from left ventricular myocytes in ANP model established by retrograde injection of 3 5% sodium taurocholate 2 5 mL/kg into pancreatic duct. RESULTS: Peak I Na current density (at -30 mV) was significantly reduced in ANP [(12 45?2 26) pA/pF, n =16] compared with sham [(25 32?3 31) pA/pF, n= 14], P
