Expression and clinical significance of DNA topoisomerase and glutathione S-transferases in acute leukemia
- VernacularTitle:DNA拓扑异构酶和谷胱甘肽S转移酶介导的机制在急性白血病临床耐药中作用的探讨
- Author:
Jing ZHENG
;
Jianda HU
;
Xinji CHEN
;
Xiaoli CHEN
- Publication Type:Journal Article
- Keywords:
Leukemia;
Drug resistance, multiple;
DNA topoisomerases;
Glutathione-transferases
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the relationship between the expressions of DNA topoisomerase (Topo), glutathione S-transferases (GSTs) and chemotherapy response, prognosis in acute leukemia (AL). METHODS: Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to detect the mRNA expression of TopoⅠ, Ⅱ?, Ⅱ? and GST?, ? from patients with AL. RESULTS: The results showed that the relative mRNA expression level of TopoⅡ?, TopoⅡ? and GST ? in AL group were significantly higher than that in normal subjects. GST?, however, was exactly reverse ( P
