Expression of VEGFR-3, CD31 and their correlation with metastasis in ovarian epithelial tumors
- VernacularTitle:卵巢上皮肿瘤血管内皮生长因子受体3和CD31表达与肿瘤转移的研究
- Author:
Mingxing DING
;
Jicheng LI
;
Miaoxi YANG
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Neoplasm metastasis;
Receptors, vascular endothelial growth factor;
Antigens, CD31
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of vascular endothelial growth factor receptor-3 (VEGFR-3) and CD31 in relation to metastasis in ovarian epithelial tumors. METHODS: VEGFR-3 and CD31 expression were examined by immunohistochemical methods, VEGFR-3 positive microlymphatic count (MLC) and microvessel density (MVD) were assessed by the image analysis. RESULTS: Both MLC and MVD in ovarian epithelial carcinomas were higher than those in benign tumors(MLC, P 0 05). CONCLUSIONS: VEGFR-3 and CD31 expression correlate significantly with metastasis, MLC and MVD might predict peritumoral lymphangiogenesis and angiogenesis, which may be as a biologic marker for metastasis in ovarian epithelial tumors. [
