Influence of IL-1? gene polymorphism on the transcription of IL-1? mRNA in patients with rheumatoid arthritis
- VernacularTitle:IL-1?基因多态性对RA患者PBMCIL-1? mRNA表达的影响
- Author:
Yunfeng PAN
;
Peida YIN
;
Meian TANG
;
Donghua HE
;
Caisheng LU
;
Xueqin YU
- Publication Type:Journal Article
- Keywords:
Interleukin-1;
Gene polymorphism;
Arthritis, rheumatoid
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of IL-1 gene polymorphism on the expression of IL-1? mRNA in patients with rheumatoid arthritis. METHODS: The method of FQ-RT-PCR was used to detect the expression of IL-1? mRNA in peripheral blood mononuclear cells separated from rheumatoid arthritis patients with different IL-1? genotype. RESULTS: The expression levels of IL-1? mRNA in 20 patients who carried IL-1? 2*2 genotype were higher than patients who carried no 2*2 genotype and normal subjects. Significant difference existed among three groups. CONCLUSION: IL-1? gene polymorphism influences the transcription of IL-1?. [
