Expression and modulation of connective tissue growth factor in renal interstitial fibrosis
- VernacularTitle:结缔组织生长因子在肾间质纤维化中的表达及其调控
- Author:
Yan LIU
;
Junming FAN
- Publication Type:Journal Article
- Keywords:
Connective tissue growth factor;
Transforming growth factor-?;
Renal interstitial fibrosis
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
CTGF, a member of the CCN family of immediate early genes, is a recently discovered profibrotic growth factor, which is involved in many pathophysiologic procedures. CTGF acts as a downstream effector of TGF-? acting on interstitial cells to enhance the progression of fibrotic renal diseases. It has been shown that CTGF gene expression can be induced or blocked by some kinds of cytokine and drugs. It is an interesting candidate target for future intervention strategies of renal interstitial fibrosis. [
