Bone-marrow-derived endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
- VernacularTitle:骨髓源性血管内皮前体细胞与出生后生理性和病理性血管形成
- Author:
Wei ZHENG
;
Xianghong YANG
- Publication Type:Journal Article
- Keywords:
Bone marrow;
Endothelial progenitor cells;
Neovascularization, pathologic;
Neovascularization, physiologic
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial progenitor cells (EPCs) exist in bone marrow, umbilical cord blood and peripheral blood of adult mammals, including humans. Furthermore, the discovery of EPCs has led to the notion of adult vasculogenesis, in which bone marrow (BM)-derived EPCs home to and incorporate into sites of new blood vessel formation, where they differentiate into endothelial cells, which is consistent with postnatal vasculogenesis. It has become apparent that circulating BM-derived EPCs are involved in promoting physiologic and pathologic neovascularization, such as wound healing and tumor growth. They are of great clinical importance in pro- or anti-angiogenic therapies. [
