The function of GAP-43 on the recovery of brain injury
- VernacularTitle:神经生长相关蛋白在脑损伤修复中的作用
- Author:
Lin LIU
;
Yanhui CHEN
;
Daguang CHEN
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Neuronal grouth associated protein
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Neuronal growth associated protein (GAP-43) is a membrane bound phosphoprotein found in the axonal growth cones of sprouting central nervous system axons. It is neuron specific and is proposed to play a critical role in growth cone function during development of the nervous system or the regenerative recovery from axon injury. The injury leads to the transfection of fibroblasts with the GAP-43 gene, which result in increasing GAP-43 expression. GAP-43 is expressed at high levels during the course of recovery of brain injury. GAP-43 acts with calmodulin and G protein to regulate metabolic responses that initates axonal growth. It is important to reestablish neuronal structure and axonal sprouting. The level of GAP-43 returns to basal level once sprouting has finished. So more and more researchers attach importance to the study of GAP-43, which will improve the level of treatment with brain injury. [
