Expression and Significance of VEGF and Type Ⅳ Collagen in the Kidney of Diabetic Rats
- VernacularTitle:糖尿病大鼠肾脏VEGF和Ⅳ-C的表达及意义
- Author:
Jing LI
;
Yingchun YE
;
Yan BAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Diabetic nephropathy;
Endothelial growth factor;
Type Ⅳ collagen
- From:
Journal of Chinese Physician
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between the expression of vascular endothelial growth factor (VEGF) and type Ⅳ collagen and the renal lesion of diabetes mellitus in diabetic rats. Methods Wistar rats were divided at random into normal control group(NC group) and diabetic model group(DM group), each group containing 20 animals. The rats models of diabetic mellitus were induced by streptozotocin(STZ). At the 8th week after induction, the expression levels of VEGF and type IV collagen in the kidney tissues in the two groups of rats were detected using immunohistochemistry. At the same time, the renal function of the rats was measured. Results At the 8th week,the expression levels of VEGF and type IV collagen of kidney tissues in DM group was much higher than those in NC group(P
