The Changes of Plasma Chemokines Levels in Patients with Congestive Heart Failure
- VernacularTitle:充血性心力衰竭患者血浆趋化因子水平变化的研究
- Author:
Aihua LI
;
Kaizheng GONG
;
Shundi WANG
- Publication Type:Journal Article
- Keywords:
Congestive heart failure;
Cytokine;
Monocyte chemoattractant protein-1;
Interleukin-8
- From:
Journal of Chinese Physician
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the plasma level of chemokines and clinical condition in patients with congestive heart failure (CHF). Methods The plasma levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) were measured in 62 patients with CHF (NYHA II～IV) and 18 healthy control subjects by ELISA and RIA, respectively. Results The levels of MCP-1 and IL-8 were significantly higher in CHF group than those in control group, and had a gradual increase along with the increasing of NYHA functional class. The increase of the chemokines levels was independent on the cause of the heart failure. The plasma MCP-1 level was significantly correlated with left ventricular ejection fraction, 6-minite walk distance, quality of life scores, and left ventricular end diastolic diameter, respectively(r=-0 422, -0 292, -0 421, 0 263, all P
