The Expression of Neural Cell Adhesion Molecule CD_(56) in the Human Lung Cancer
- VernacularTitle:神经细胞黏附分子CD_(56)在肺癌中的表达
- Author:
Zhenhong HU
;
Qilin PENG
;
Zuhong FU
- Publication Type:Journal Article
- Keywords:
Lung neoplasm/small cell;
Neural cell adhesion molecule;
Immunohistochemistry
- From:
Journal of Chinese Physician
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of neural cell adhesion molecule CD 56 in the human lung cancer and its pathological significance. Methods 59 paraffin imbedded specimens of lung cancers were collected and human small cell lung cancer H128 cell line was cultured.The CD 56 expression in the lung cancer tissues and H128 cells was detected by immunohistochemical method. Results The expression of CD 56 was positive in 35 of 43 NSLC specimens, and the other specimens showed weakly positive staining. All 19 cases of the SCLC specimens showed CD 56 positive staining, 12 specimens of which were strongly positive. There was a significant difference in CD 56 expression between the SCLC and NSCLC. CD 56 was extensively expressed in H128 cells. Conclusion CD 56 might be an ideal tumour marker for SCLC.
