The Level and Significance of Serum IL-18 and sFas/sFasL in Patients with COPD
- VernacularTitle:COPD患者血清IL-18和sFas/sFasL的水平及意义
- Author:
Songmin ZHUO
;
Ruihuan XU
;
Zhen MA
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
IL-18;
Cell apoptosis;
Fas;
FasL
- From:
Journal of Chinese Physician
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level change and correlation of serum IL-18 and soluble Fas/Fas ligand(sFas/sFasL) in patients with chronic obstructive pulmonary disease (COPD) to evaluate their roles in the pathogenesis of COPD. Methods The levels of serum IL-18 and sFas/sFasL in 36 patients with COPD of acute aggravation stage and 20 healthy control subjects were detected by ELISA. Results The levels of serum sFasL and IL-18 in patients with COPD were significantly lower than those in healthy control subjects, while there was not significant differene in serum sFas level between the two groups. Conclusion The serum sFasL and IL-18 level decreass in patients with COPD of acute aggravation stage indicated that cell apoptosis level and immune function reduced in the patients.
