Experimental Study on the Factors Affecting in Vitro Dissolubility of Total Puerariae Flavones Bioadhesive Tablets
- VernacularTitle:影响葛根总黄酮生物粘附片体外释放度的因素研究
- Author:
Daxiong XIANG
;
Huande LI
;
Hongbo YUAN
;
Yinxiang SUN
- Publication Type:Journal Article
- Keywords:
total puerariae flavones;
bioadhesive tablet;
dissolubility;
affecting factor
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the main factors affecting in vitro dissolubility of total puerariae flavones(TPF)bioad?hesive tablets.METHODS:Using HPMC,Carbopol(CP934NP)as bioadhesive and base materials,lactose as porogenic agent to prepare bioadhesive tablets;Basket-rotating method was adopted to determine the dissolubility while0.1mol/L HCl was used as dissolution medium,Rotational speed was100r/min.The accumulated dissolution was detected and the influence of the amount of HPMC,CP,kind of porogenic agent,amount of lactose,size of granules in pressed tablets and medium pH on dissolubility was observed.RESULTS&CONCLUSION:The amount of HPMC,CP and lactose,kind of porogenic agent,size of granules in tablets and medium pH can affect the dissolubility of bioadhesive tablets.
