Pharmacokinetics of Single Cefoperazone Sodium and Cefoperazone Plus Tazobactam in Dogs
- VernacularTitle:头孢哌酮及其与他唑巴坦的复方制剂在家犬体内的药动学研究
- Author:
Xiaojiang WANG
;
Yu ZHAO
- Publication Type:Journal Article
- Keywords:
Cefoperazone Sodium;
Tazobactam Sodium;
pharmacokinetics;
HPLC
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetics of Cefoperazone in dogs and compare the pharmacokinetic differ?ence between single Cefoperazone and Cefoperazone plus Tazobactam.METHODS:Six healthy dogs were given intravenously a single dose of Cefoperazone Sodium and Cefoperazone-Tazobactam Sodium.Levels of Cefoperazone in dogs'serum were de?termined by RP-HPLC method.The pharmacokinetic parameters were obtained and compared between Cefoperazone Sodium and Cefoperazone-Tazobactam Sodium.RESULTS:The serum drug concentration-time course in dogs was conformed to the two-compartment model after a single dose of Cefoperazone Sodium and Cefoperazone-Tazobactam Sodium.Area under the concentration-time curve(AUC 0～∞ )was(486.17?117.98)、(469.74?71.49)(mg?h)/L,half-time(T 1/2? )was(0.96? 0.13)、(0.85?0.17)h,respectively.There were no significant differences between two groups.CONCLUSION:Taking AUC 0～∞ as index,two preparations are bioequivalent.
