Long-term effects of TCV116 on left ventricular remodeling and heart function after myocardial infarction in rats
- VernacularTitle:长期TCV116干预对心肌梗死后心室重塑及心功能的影响
- Author:
Zewei TAO
;
Yuanwei HUANG
;
Yao WANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Ventricular remodeling;
Angiotensin Il;
Receptors, angiotensin antagonist
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of long-term TCV116 on left ventricular remodeling and heart function after myocardial infarction. METHODS: Myocardial infarction (MI) was caused by ligation of the left anterior descending coronary artery in rats. One week after the surgical performance, the surviving rats were randomly assigned to the following treatment protocols: (1) MI rats with no therapy; (2) MI rats treated with TCV116 2 mg/kg per day; (3) Sham-operated control; (4) Sham-operated rats, treated with TCV116 2 mg/kg per day. At 22 weeks, cardiac hemodynamic parameters such as MAP, LVSP, dp/dt_(max) and LVEDP, and histomorphometric parameters such as (LVW/BW) and LVCA/BW were measured, mRNA of cardiac genes such as ?MHC, BNP, TGF-?_1, collagen I and III were quantified, and survival rates were calculated. RESULTS: Compared with sham-operated rats, MI rats without therapy showed significant increases in histomorphometric parameters as well as in mRAN expressions of cardiac genes (P
