Cortical gene expression pattern in rat focal cerebral ischemia
- VernacularTitle:基因表达谱芯片筛选局灶性脑缺血大鼠脑相关基因的研究
- Author:
Zhanjun ZHANG
;
Kang YING
;
Zhong WANG
;
Xiaoyan ZHANG
;
Jianxun LIU
;
Yan HUANG
;
Li XU
;
Cuie WEI
;
Yongyan WANG
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Gene expression profiling;
Oligonucleotide array sequence analysis;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the genes differential expression in cortex during rat focal cerebral ischemia. METHODS: cDNA microarray chips containing numerous cDNAs were used to investigate the gene expression pattern between samples of focal cerebral ischemia and sham-control operation rats. RESULTS: Two hundred and eleven genes differentially expressed were screened out, among these genes, up-and down-regulated genes were 199 and 12, respectively. CONCLUSIONS: The analysis of gene expression pattern of focal cerebral ischemia based on cDNA microarray can realize high-throughput screening of the genes associated with the focal cerebral ischemia. The differential expression of genes may be related to the pathogenesis of focal cerebral ischemic diseases.
