Effect of fibrinogen, fibrin and fibrin degradation products on the proliferation and migration of human vascular smooth muscle cells
- VernacularTitle:纤维蛋白原对人血管平滑肌细胞株增殖和移行的影响
- Author:
Yaling HAN
;
Jian ZHANG
;
Jian KANG
;
Xiaozeng WANG
- Publication Type:Journal Article
- Keywords:
Vascular smooth muscle cells;
Fibrinogen;
Arteriosclerosis
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of fibrinogen (Fg), fibrin (Fb) and fibrin degradation products (FDPs) on the proliferation and migration of human vascular smooth muscle cells (VSMC).METHODS: The effects of Fg, Fb and FDPs on the proliferation of VSMC were observed by means of cell counting and MTT test, migration assays were performed using the wounding model and the transwell cell culture apparatus.RESULTS: Fg itself did not stimulate the proliferation of VSMC, but stimulated VSMC migration. Fb and FDPs both stimulated the proliferation and migration of VSMC, meanwhile the effect of Fb was in a dose-dependent manner.CONCLUSION: Fb, in particular FDPs, may play an important role by stimulating the proliferation and migration of VSMC in restenosis and atherogenesis.
