Alteration of transient outward potassium current in ventricular myocytes from 1-week and 2-month infarcted rabbit hearts
- VernacularTitle:兔心肌梗死1周及2月后心室肌细胞瞬间外向钾电流的变化
- Author:
Chao DING
;
Zhenshan HE
;
Junyu CUI
;
Li YANG
;
Qiao SHI
;
Liye HU
;
Shuying QI
;
Xiaoyun LIU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Transient outward potassium current;
Myocardium;
Patch-clamp techniques
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the current density of transient outward potassium current (I_(to)) in cells from the epicardial zone of the 1-week and 2-month infarcted rabbit heart. METHODS: Rabbits were infarcted by ligation of the left anterior descending coronary artery, 1 week as well as 2 months later, the single ventricular myocytes were isolated enzymatically from the infracted area of 1-week infracted rabbit heart (PMI-1 week) and 2-month infracted heart (PMI-2 months), region remote from the infracted zone of 2-month infracted heart (REM-2 months) and free wall of left ventricule from noninfarcted heart (CON). I_(to) was recorded using whole cell patch-clamp techniques. (RESULTS:) Membrane capacitance of myocytes in REM-2 months group was signifitantly larger than that in CON. I_(to)current density (at +60 mV) was significantly reduced in PMI-1 week [(7.5?2.4) pA/pF, n=12] and PMI-2 months [(10.6?4.1) pA/pF, n=18] compared with CON [(17.4?5.2) pA/pF, n=16], P
