Effect of dexamethasone or theophylline on platelet-activating factor-induced eosinophils
- VernacularTitle:地塞米松或茶碱对血小板活化因子诱导的嗜酸性粒细胞活化的影响
- Author:
Di WU
;
Cui ZHANG
;
Ren LIANG
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Theophylline;
Platelet activating factor;
Eosinophils
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To elucidate the effects of platelet-activating factor (PAF) on eosinophil activation and the action of dexamethasone or theophylline during this process. METHODS: Eosinophils (EOS) from the peripheral blood of normal subjects were isolated. The hypodense eosinopil (HE) and normodense eosinophil (NE) were studied with electron microscopy. The effects of PAF on eosinophil activation and the action of dexamethasone or theophylline during the above process were measured. RESULTS: Hypodense eosinophil had significantly smaller individual granules than normodense eosinophil had. PAF induced eosinophil peroxidase release, and generated. Eosinophils incubated with 10~(-8) mmol/L PAF and 10~(-5) mmol/L dexamethasone released (101.17?10.32) mg/L eosinophil peroxidase (P
