Structure, receptor and pathophysiological function of natriuretic peptide
- VernacularTitle:利钠肽结构、受体的生理和病理作用
- Author:
Li XU
;
Lanying CHEN
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide;
Cardiovascular diseases;
Immunity
- From:
Chinese Journal of Pathophysiology
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Five natriuretic peptides (NP) have been identified: A-type, B-type, C-type, D-type and V-type. All of them have ringed-structures. The actions of the natriuretic peptides are modulated through their cognate receptors, which are named as NPR-A,NPR-B and NPR-C. The receptors are involved in the cGMP-dependent signaling cascades,which take part in many different physiological regulation, such as diureses,vasodilatation, depressing blood pressure, improving immunity, promoting development of bone, regulating nerve system and so on. At present, ANP and BNP have become a marker in diagnostic some cardiovascular diseases.
