The Effect of Pravastatin on the Non-diabetic Nephropathy Patients with Chronic Renal Failure
- VernacularTitle:普拉固在非糖尿病肾病早期肾功能衰竭治疗中的应用
- Author:
Kun WU
;
Jingyan ZHANG
;
Lijun ZHU
- Publication Type:Journal Article
- Keywords:
hydroxy-3-methylglutaryl CoA reductase inhibitor;
Chronic renal failure;
Non-diabetic nephropathy;
Pravastatin
- From:
Journal of Chinese Physician
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of pravastatin on the patients with chronic renal failure(CRF)and normal blood lipid. Methods 48 cases of CRF patients with normal blood lipid were randomly divided into two groups. 26 patients of group 1 were given pravastatin besides basic treatment. 22 patients of group 2 were only given basic treatment. The treatment was consecutive for one year. Blood lipid, serum creatinine, clearance rate of serum creatinine(Ccr), urinary retinol-binding protein(RBP) and protein amount in urine were tested respectively before treatment and one month, six months and one year after the treatment. Results Compared with the patients of group 2, blood lipid, urinary RBP and total urinary proteins and serum creatinne decreased, and Ccr increased in the patients of group 1. Conclusion Pravastatin can postpone the renal dysfunction of the CRF patients with nomal blood lipid.
