Effect of 1 mg of prophylactic haloperidol for postoperative nausea and vomiting after gynecological laparoscopic surgery using IV patient controlled analgesia.
- Author:
Young Eun MOON
1
;
Hyun Do JUNG
;
Keon Hee RYU
;
Dong Eon MOON
Author Information
1. Department of Anesthesiology and Pain Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. demoon@catholic.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Haloperidol;
Laparoscopic surgery;
Patient-controlled analgesia;
Postoperative nausea and vomiting
- MeSH:
Adult;
Analgesia, Patient-Controlled;
Antiemetics;
Arrhythmias, Cardiac;
Droperidol;
Female;
Haloperidol;
Humans;
Incidence;
Laparoscopy;
Nausea;
Passive Cutaneous Anaphylaxis;
Postoperative Nausea and Vomiting;
Vomiting
- From:Anesthesia and Pain Medicine
2010;5(1):30-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Haloperidol, a major tranquilizer similar to droperidol, has been found to have a potent antiemetic effect on postoperative nausea and vomiting (PONV), but the supporting evidence was incomplete, especially in Korea.Therefore we evaluated the prophylactic effect of haloperidol on opioid-based IV patient-controlled analgesia (PCA) related PONV in susceptible patients after gynecological laparoscopic surgery. METHODS: Ninety-six adult women scheduled gynecological laparoscopic surgery were enrolled in a randomized, double-blinded and placebo study.Patients received haloperidol 1 mg (Group H) or saline (Group C) 30 min before the end of surgery.Fentanyl-based IV PCA was administered after surgery.The incidences and severity of nausea, vomiting, rescue antiemetic administration, pain, and adverse effects (cardiac arrhythmias and extrapyramidal effects) were assessed for 24 h after surgery.The sedation score was recorded in the post-anesthesia care unit for 2 h. RESULTS: The incidences and severity of nausea and the number of antiemetic administration were significantly lower in Group H than Group C (P < 0.05). But the sedation and pain score were similar. There was no QTc prolongation or extrapyramidal symptom in both groups. CONCLUSIONS: Prophylactic haloperidol 1 mg is effective in preventing PONV related to fentanyl-based IV PCA, with less adverse effects, in patients undergoing gynecological laparoscopic surgery.
