Effects of N-acetylcysteine on Alcoholism in Mice
- VernacularTitle:乙酰半胱氨酸对小鼠酒精中毒的影响
- Author:
Yongping HUANG
;
Shiwen ZHOU
;
Ying XU
;
Jianlin TANG
;
Lian WANG
;
Jinyuan ZHANG
;
Xue YANG
- Publication Type:Journal Article
- Keywords:
N-acetylcysteine;
alcohol dehydrogenase;
ethanol;
righting reflex
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of N-acetylcysteine(NAC)on the concentration of ethanol in serum and the activities of alcohol dehydrogenase in liver and stomach tissue in alcoholic mice.METHODS:All mice were given p.o white spirit30min after p.o saline or5%NAC solution,and the durations from the disappear of righting reflex to recovery in mice were recorded and the number of dead mice in24hours were countered;With the same procedure for six days,the mice were killed by withdrawaling blood from orbit,and taken out the liver and stomach immediately,the concentrations of ethanol in serum and the activities of alcohol dehydrogenase in liver and stomach were measured by chromatometry and colorimetric method respectively.RESULTS:In drunk test,5%NAC solution significantly postponed the time from p.o white spirit to the disappear of righting reflex(P
