Experimental study of glycynhizin in the prevention of colonic cancer after cholecystectomy
- VernacularTitle:甘草甜素预防胆囊切除后大肠癌的实验研究
- Author:
Qinqiao FAN
;
Weifeng YANG
;
Liqiao FAN
;
Fu QIU
- Publication Type:Journal Article
- Keywords:
CHOLECYSTECTOMY/adv eff;
COLORECTAL NEOPLASMS/etiol;
COLORECTAL,NEOPLASMS/prev;
GLYCYNHIZIN/(ther) use
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and the mechanism of glycynhizin in the prevention of colonic cancer (after) cholecystectomy. Methods Sixty mice were randomly divided into 3 groups: Sham group(S group),group of model of colonic cancer after cholecystectomy(C group) and glycynhizin treatment group(GL group). The incidence of colonic cancer, expressions of p53 mRNA,p21 mRNA and bcl-2mRNA and the activity of NF-?B were tested. Results The incidence of colonic cancer in C group was significantly higher than that in GL group (P
