The role of autoantibodies against angiotensin Ⅱ type 1-receptor in the pathogenesis in preeclampsia
- VernacularTitle:抗血管紧张素Ⅱ受体1型自身抗体在妊高征发病机制中的作用
- Author:
Chaoying WU
;
Jianwen ZHU
;
Feitao DENG
- Publication Type:Journal Article
- Keywords:
Pregnancy complications,cardiovascular;
Hypertension;
Autoantibodies;
Receptors,angiotensin
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of the autoantibodies against angiotensinⅡ type 1 receptor (ATR-1) in the pathogenesis of preeclampsia. Methods Forty normotensive and 46 pregnant women with preeclampsia were recruited in this study. Synthesized ATR-1 polypeptide fragment was used as antigens to screen the autoantibodies against ATR-1 by ELISA. The level of angiotensinⅡ was also examined. Results The positive rate of the ATR-1 antibodies and plasma level of angiotensin Ⅱ in patients with preeclampsia [63.0%(29/46) and (92.54?37.22) pmol/L] were significantly higher than those in normotensives [7.5% (3/40) and (25.75?12.33) pmol/L, P
