The level of serum leptin in GDM mothers and their neonates and the expression of leptin in placenta
- VernacularTitle:妊娠期糖尿病母儿血清瘦素水平及胎盘瘦素的表达
- Author:
Tong LIU
;
Tao SHANG
;
Zhong TIAN
- Publication Type:Journal Article
- Keywords:
Diabetes,gestational;
Insulin;
Leptin;
Placenta
- From:
Chinese Journal of Perinatal Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of leptin in the serum of GDM mothers and their neonates and the variation of the leptin expression in placenta. Methods The concentrations of serum insulin and leptin in 24 GDM and 26 healthy mothers and neonates were examined by radioimmunoassay (RIA).The level of leptin mRNA in 50 placentas was examined by reverse transcription-polymerase chain reaction(RT-PCR). Results (1) The serum levels of leptin and insulin in GDM group [(18.62?7.86) ?g/L and (13.47?5.11) mIU/L] were significantly higher than those in control group [(14.21?7.59) ?g/L and (8.98?4.23) mIU/L,P 0.05) in both groups. But the leptin level in umbilical blood of the two group was positively related to the insulin level ( r=0.53,P
