Effects of tyrosine phosphatase inhibitor on tau phosphorylation in vivo
- VernacularTitle:酪氨酸磷酸酯酶抑制剂对tau蛋白磷酸化作用的研究
- Author:
Xinwen ZHOU
;
Huiliang WU
;
Weili CAO
;
Lijuan MA
;
Jianzhi WANG
- Publication Type:Journal Article
- Keywords:
Protein tyrosine-phosphatase;
tau proteins;
Phosphorylation
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of receptor tyrosine kinase system mediated by phosphotyrosine phosphatase (PTP) on tau phosphorylation in rat hippocampus. METHODS: Pervanadate (PVN), inhibitor of PTP or inhibitor of glycogen synthase kinase-3 (GSK-3), LiCl were injected into rat hippocampus by stereotaxy technique. The level of tau phosphorylation was detected by Western blot and immunohistochemistry after 24 h of injection. RESULTS: PVN significantly inhibited tau phosphorylation at PHF-1 epitope and the inhibition of tau phosphorylation by PVN was stronger than that of LiCl (P
