Mutation of the transforming growth factor-? typeⅡ receptor gene in sporadic colorectal cancers with microsatellite instability
- VernacularTitle:伴有微卫星不稳定性的散发性结直肠癌转化生长因子 -betaⅡ型受体基因突变的研究(英文)
- Author:
Jinming DI
;
Li SUN
;
Qiong WU
;
Yichu ZHANG
;
Qinlong GU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Microsatellite instability;
Receptors, transforming growth factor beta;
Mutation
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine the relationship between the mutation of the RII gene and RER status in the tumorigenesis of sporadic colorectal cancer. METHODS: We screened RER status and mutation of the RII gene from 50 sporadic colorectal cancers (19 in the proximal colon, 31 in the distal colorectum). RESULTS: RER was found in 13 cases (8 in the proximal colon, 5 in the distal colorectum), and 5 of them showed mutations of the RII gene. All 5 cancers carrying a TGF-? RII gene mutation showed RER+, but there wasn't any mutation of RII gene in RER(-) cases. Four of 5 RII mutation were located at the cecum. CONCLUSION: These data indicate that the TGF-? RII gene is a major target of microsatellite instability and mutation of the RII gene play an important role in carcinogenesis of sporadic colorectal cancer with microsatellite instability, especially at the cecum. [
