Effect of inactivated SARS coronavirus vaccine on mouse organs
- VernacularTitle:灭活SARS冠状病毒疫苗对小鼠脏器影响的实验研究
- Author:
Bin DU
;
Xueyun ZHONG
;
Sheng XIONG
;
Chuanhai ZHANG
;
Xinjian LIU
;
Shisheng LIU
;
Meiying ZHANG
;
Jiuxiang LI
;
Yifei WANG
;
Jiahai LU
;
Zhuoyue WAN
;
Xinge YAN
;
Huanying ZHENG
;
Jianglin FAN
- Publication Type:Journal Article
- Keywords:
Severe acute respiratory syndrome;
Coronavirus;
Vaccines, inactivated;
Mice
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the pathological change in mouse organs immunitied by inactivated SARS-CoV vaccine. METHODS: Inactivated SARS-CoV vaccine was injected into BALB/c and C57BL/6 mice. Anti-SARS antibody was analyzed by ELISA. After 8 weeks, the immunitied mice were killed and those organs were analyzed by pathological methods. RESULTS: Anti-SARS antibody in mice was positive after 8 days. Only minimal injury was observed in a few lungs and livers, but the other organs were not. CONCLUSIONS: Inactivated SARS-CoV vaccine induced mice to create antibody, whereas they did not cause severe injury. This result will be valuable for vaccine into clinical research. [
