Action of NF-?B p65 in renal interstitium in rats with active Heymann nephritis
- VernacularTitle:主动性Heymann肾炎中NF-?Bp65在肾间质病变中的作用
- Author:
Xiaogang DU
;
Hua GAN
;
Gang XIAO
- Publication Type:Journal Article
- Keywords:
Nephritis;
Tubule-interstitium;
NF-kappa B
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the action of NF-?B p65 in tubule-interstitium in rats with active Heymann nephritis(AHN). METHODS: Twenty female Wistar rats in 6-8 weeks of age were divided into two groups. The nephritis was induced with Fx1A/CFA by subcutaneous injection and with CFA as control. After rats were killed, the activation of NF-?B p65 in renal tissue was observed by immune histochemistry. RESULTS: The lesion score of renal interstitium and activation of NF-?B p65 of renal tubule in rats with AHN was higher than those of control group(P
