Effect of atrial natriuretic peptide on acute lung injury induced by lipopolysaccharide
- VernacularTitle:心房钠尿肽对脂多糖所致大鼠急性肺损伤的影响
- Author:
Bin JIA
;
Zhichao LI
;
Mingqing DONG
;
Lili ZHANG
;
Haowen QI
- Publication Type:Journal Article
- Keywords:
Atrial natriuretic factor;
Lipopolysaccharides;
Respiratory disease syndrome, adult;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate effect of atrial natriuretic peptide (ANP) on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in rat. METHODS: Mean arterial blood pressure (MAP) was recorded with model 6280 physiology intelligentialize grapher, nitric oxide (NO) and endothelin (ET) concentrations in plasma were measured after lipopolysaccharide (LPS) or following LPS ,ANP was injected into vein in rats. After experiment,lung water as well as pulmonary histopathological changes was measured and observed, respectively. RESULTS: Administration of LPS elicited a persistence decrease in MAP (8.1 kPa?2.6 kPa,at 4 h,P0.05); The histopathological of lung displayed markedly improved. CONCLUSION: ANP attenuates ALI induced by LPS in the rat. The effect of ANP may be via decreasing secretion of ET,NO and regulation arterial blood pressure. [
