Relationship between TGF ?1 expression and apoptosis in hepatocytes during acute hemorrhagic necrotic pancreatitis
- VernacularTitle:实验性急性出血坏死性胰腺炎肝转化生长因子?1与肝细胞凋亡
- Author:
Haiyan LI
;
Ruifen CHEN
;
Guozhen LIU
;
Jue WANG
;
Xingcui WANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis, acute necrotizing;
Liver;
Apoptosis;
Transforming growth factor beta
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the expression of TGF ?1 in hepatocytes during acute hemorrhagic and necrotic pancreatitis (AHNP) and to study the relationship between TGF ?1 and apoptosis in hepatocytes. METHODS: AHNP was induced in 40 rats weighting 260-280 g by intraductal administration of 5% sodium taurocholate. The pathologic morphologic changes of liver and pancreas were observed under light microscope. The hepatocyte apoptosis was examined through TdT (terminal deoxynucleotidyl transferase) mediated dUTP nick end labeling (TUNEL) and the expression of TGF ?1 in hepatocytes was analyzed through immunohistochemistry. RESULTS: The liver injuries were found at 3 h after the inducement. These changes were aggravated with the development of the disease. The apoptotic hepatocytes were found after 3 h (P
