Changes of serum T-PSA, F-PSA and F/T ratio in patients with prostate cancer and its clinical significance
- VernacularTitle:前列腺癌患者血清T-PSA、F-PSA水平和F/T比值变化及临床意义
- Author:
Guoping ZHAO
;
Jiansheng LAI
;
Weigang HUANG
;
Jin LIN
;
Shengli XU
- Publication Type:Journal Article
- Keywords:
Prostate-specific antigen;
Prostatic neoplasms;
Prostatic hyperplasia
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the changes of serum total prostate specific antigen (T-PSA), free prostate specific antigen (F-PSA) and the ratio of F-PSA to T-PSA (F/T) in patients with prostate cancer (PCa) and its clinical significance. METHODS: The concentrations of T-PSA and F-PSA in serum were measured by micropartical enzyme immunoassay (MEIA) using AxSYM System, and the F/T ratio was calculated. RESULTS: Before operation, the concentrations of T-PSA and F-PSA in patients with PCa were much higher and F/T ratio was significantly lower than that in patients with benign prostate hyperplasia (BPH). T-PSA and F-PSA levels decreased, but F/T ratio increased after operation in PCa and BPH. F/T ratio in 83.5% PCa and 6.5% BPH was less than 0.16. To diagnosis PCa, the sensitivity of F/T ratio was 83.5%, and the specificity was 86.7%. CONCLUSION: Serum T-PSA, F-PSA and F/T ratio are important parameters for the early diagnosis of prostate cancer. [
