Cytosolic proteins NODs involved in the regulation of immune and inflammatory responses
- VernacularTitle:参与免疫及炎症反应调控的胞浆蛋白NODs
- Author:
Chaofeng HU
- Publication Type:Journal Article
- Keywords:
NOD proteins;
Inflammation;
Immunity;
Apoptosis
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotide-binding oligomerization domain (NOD) proteins are members of a growing family of cytosolic factors related to the apoptosis regulator Apaf-1 and a class of plant disease resistance proteins. NOD proteins have been implicated in the induction of NF-?B activity and in the activation of caspases. Biochemical evidence has unraveled the role of NOD1 and NOD2 as intracellular sensors of bacterial peptidoglycan. Notably, genetic variation in the genes encoding the NOD proteins NOD2, cryopyrin and CⅡTA in humans is associated with inflammatory disease or increased susceptibility to bacterial infections. NOD proteins may be involved in the recognition of microorganisms and regulation of inflammatory responses. [
