Expression of MMP-9 and TIMP-1 Proteins in the Decidua and Villi of Early Pregnancy
- VernacularTitle:早孕蜕膜绒毛基质金属蛋白酶-9和其基质金属蛋白酶抑制物-1的表达特点及作用
- Author:
Wenwu GUI
;
Yan QIU
;
Shiqiong ZHANG
- Publication Type:Journal Article
- Keywords:
Early pregnancy;
Decidua;
Villi;
MMP-9;
TIMP-1
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) proteins in the decidua and villi of the early pregnancy. Methods Immunohistochemical staining was applied to detect the expression of MMP-9 and TIMP-1 proteins in the decidua and villi of 45 the early pregnant women and in the mid-secretory phase endometrium of 30 normal women. Results The OD of MMP-9 and TIMP-1 proteins expression in the decidua and villi was 0 168?0 055 and 0 155?0 046 respectively, in the mid-secretory phase endometrium were 0 133?0 0210 and 0 113?0 0251 respectively, and the expressions of MMP-9 and TIMP-1 in the early pregnancy increased significantly when compared with the mid-secretory phase endometrium(P
