Study on the Correlation among the p53 Protein Expression, Tumor Biological Behavior, p53 Gene Mutation and EBV Infection in NPC
- VernacularTitle:鼻咽癌p53蛋白与生物学行为及p53基因突变和EB病毒感染的相关研究
- Author:
Xiaoming ZHAO
;
Guojun XIONG
;
Xiaohui DOU
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
p53 gene;
p53 protien;
Epstein-Barr virus
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate p53 protein expression in nasopharyngeal carcinoma (NPC) and its correlation with biological behavior, p53 gene mutation and EBV infection in 43 cases of NPC. Methods Immunohistochemical staining was applied to detect p53 protein,PCR-SSCP was used to detect p53 gene mutation, and EBV infection was determined with PCR. Results The positive rate of p53 protein expression was 76 7%(33/43)in the NPC. The positive rate of p53 protein expression in stages Ⅲ and Ⅳ was significantly higher (80 6%) than that in stages Ⅰ and Ⅱ(66 6%) (P
