Treatment of Herpes Zoster with Recombinant Interferon (IFN alfa-1b) Cream: A Randomized, Double-blind, Placebo-controlled, Multi-center Clinical Trial
- VernacularTitle:外用重组人干扰素?-1b乳膏治疗带状疱疹多中心随机、双盲临床研究
- Author:
Hong JIA
;
Zhiqiang CHEN
;
Jiabi WANG
;
Zhenhui PENG
;
Fanqin ZENG
;
Lin LIN
;
Xiangsheng CHEN
;
Wenyan XU
- Publication Type:Journal Article
- Keywords:
Herpes zoster;
Administration, cutaneous;
Interferon typeⅠ, recombinant
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of topical interferon alfa-1b cream in the treatment of herpes zoster. Methods A randomized, double-blind, parallel placebo-controlled clinical study was conducted. The test drug was topically used in herpes zoster patients, three times a day for 2 weeks. Patients whose skin lesions cleared completely were followed for 29 days to observe postherpetic neuralgia. Results One hundred and twenty-eight patients with herpes zoster were enrolled into this trial. Sixty-five patients were randomly selected to receive interferon alfa-1b cream and sixty-three patients received vehicle cream. After following up for 11, 14, 22, 29 days the cure rates were 69.2%, 81.5%, 90.8%, 95.4% respectively in the study group and were 57.1%, 71.4%, 84.1% and 84.1% respectively in the control group(P
