Study on the Association of HLA Class Ⅱ Genes with Vitiligo in the Eastern China Han Nationality
- VernacularTitle:华东地区汉族某些HLA-Ⅱ类等位基因与白癜风的相关性研究
- Author:
Wenyu WU
;
Wenwen FU
;
Kanghuang LIAO
;
Luyan TANG
;
Jian LI
- Publication Type:Journal Article
- Keywords:
Vitiligo;
Genes, MHC classⅡ
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of HLA class Ⅱ genes and vitiligo in the eastern China Han nationality. Methods Ninety-eight patients with vitiligo and 150 healthy controls were studied for HLA-DRB1, DQA1 and DQB1 locus alleles by PCR-SSOP typing. Results The frequency of HLA-DQA1*03 increased significantly (Pc = 0.008) and DQA1*05 decreased significantly (Pc = 0.016) in the patients with vitiligo. Conclusions The results suggest that there exists a correlation between HLA class Ⅱ genes and vitiligo, and DQA1*03 allele may be a susceptible gene or have a close linkage with susceptible genes, while DQA1*05 allele may be a protective gene in the eastern China Han nationality.
