Expression of Matrix Metalloproteinase-9 and Its Tissue Inhibitor in Cutaneous Squamous Cell Carcinoma
- VernacularTitle:基质金属蛋白酶-9及其组织抑制物-1在皮肤鳞状细胞癌中的表达
- Author:
Jun FENG
;
Liehua DENG
;
Gang ZHAO
;
Tao LU
;
Guangyu JIANG
;
Chaoyong XIA
;
Jie LIU
;
Ze LIN
- Publication Type:Journal Article
- Keywords:
Carcinoma, squamous cell;
Bowen′s disease;
Gelatinase B;
Tissue inhibitor of metalloproteinases
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expression of matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor (TIMP-1) in cutaneous squamous cell carcinomas (SCC) and the relationship between the expression and invasive growth and metastasis of SCC. Methods Immunohistochemical method of streptavidin-peroxidase (SP) was used to detect the expression of MMP-9 and TIMP-1 proteins on the paraffin embedded sections of 65 patients with cutaneous SCC and 5 cases of normal epidermis. The immunohistochemical results were analyzed quantitatively using an image analysis system. Results MMP-9 and TIMP-1 proteins were diffusely expressed on the tumor nests and the mesenchymal cells around the nests, while in normal epidermis MMP-9 and TIMP-1 were weakly positive. The expression level of MMP-9 protein and the ratio of MMP-9/TIMP-1 were higher in aggressive SCC group than those SCC in situ group (t = 2.33 and 2.36, respectively, P
