The Role of IL-2, IFN-? and IL-10 in Pemphigus Acantholysis
- VernacularTitle:白介素2、干扰素?、白介素10对天疱疮棘层松解影响的研究
- Author:
Ying WANG
;
Qingchun DIAO
;
Baiyu ZHONG
;
Lu WANG
;
Fei HAO
;
Qingyi YE
- Publication Type:Journal Article
- Keywords:
Pemphigus;
Acantholysis;
Interleukin-2;
Interleukin-10;
Interferon typeⅡ
- From:
Chinese Journal of Dermatology
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of IL-2,IFN-? and IL-10 in pemphigus acantholysis. Methods Acantholysis was observed histopathologically in the skin organ culture model of pemphigus after interacting with different concentrations of IL-2, IFN-? and IL-10 for 24 h?48 h and 72 h. Results The acantholysis was promoted by IL-2 and IFN-?, and the severity of acantholysis was related to the concentrations of IL-2 and IFN-?. The effect of IFN-? was weaker than that of IL-2. IL-10 could inhibit the acantholytic effect of IFN-? significantly, and inhibit the acantholytic effect of IL-2 when its concentration was higher than 100 pg/mL. Conclusions Th1 cytokines can promote acantholysis induced by antibody of pemphigus (Pab) while Th2 cytokines can inhibit the acantholysis induced by Pab, and the effect of Th1 cytokines. Th2 lymphocytes may play an important role in the pathogenesis of pemphigus.
