Expression of HIF-1? and VEGF in Human Laryngeal Carcinoma
- VernacularTitle:喉癌肿瘤组织HIF-1?与VEGF的表达及意义
- Author:
Yidao JIANG
;
Qingquan HUA
- Publication Type:Journal Article
- Keywords:
Laryngeal carcinoma;
Hypoxia inducible factor 1 alpha;
Vascular endothelial growth factor;
Immunohistochemistry
- From:
Journal of Audiology and Speech Pathology
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the relationship between the expression of hypoxia inducible factor 1 alpha and VEGF in human laryngeal carcinoma.Methods The expression of HIF-1? and VEGF were confirmed in 68 cases of laryngeal carcinoma by S-P immunohistochemical methods.The relations between the expression of HIF-1? and VEGF were analysed by SPSS software.Results Of the 68 cases, 41 cases expressed HIF-1?. 46 cases expressed VEGF. 34 cases of the 41 HIF-1? positive cases expressed VEGF.Conclusion The expression of HIF-1? is related to the expression of VEGF. HIF-1? may promote the expression of VEGF in laryngeal carcinoma,thus further promoting tumor angiogenesis, invasion,and metastasis of the laryngeal carcinoma.
