Comparison of Protective Effects of Gene Engineering Agents,NIF,NHH or TNHH on Focal Cerebral Ischemia Injury in Rats Subjected to Middle Cerebral Artery Occlusion
- VernacularTitle:3种基因工程药物对大鼠动脉阻塞性脑损伤治疗作用的比较研究
- Author:
Hui YANG
;
Yuanda ZHOU
;
Haixia HE
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
NIF;
NHH;
TNHH;
infarct volume
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the protective effects of NIF,NHH,TNHH on focal cerebral ischemic injury induced by middle cerebral artery occlusion in rats.METHODS:24 SD rats were randomly divided into 4 groups:control group(n=6)received normal saline 0.1ml/kg,group NIF(n=6),group NHH(n=6)and group TNHH(n=6)received NIF,NHH,TNHH 2mg/kg i.v.(NIF,NHH,TNHH were dissolved in normal saline 2mg/kg)respectively just before middle cerebral artery occlusion(MCAO)with 3～0 nylon monofilament suture for 3 days.The neurological behavior was evaluated at 4hr,8hr,24h,48h,72h after operation.The infarct volume was then assessed after TTC staining following the last neurological behavior evaluation.Two specimens were randomly taken in 4 groups and were sent to HE staining.RESULTS:The neurologic defect score(NDS)of group NIF,NHH,TNHH after operation decreased significantly(P
