Preparation of Ligustrazine Hydrochloride Liposome and Evaluation of the Quality
- VernacularTitle:盐酸川芎嗪脂质体的研制及其质量评价
- Author:
Yikun HUANG
;
Juan DU
;
Jiancheng LIANG
;
Wenan QIN
;
Min WEI
- Publication Type:Journal Article
- Keywords:
ligustrazine hydrochloride;
liposome;
trial-production;
quality evaluation
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preparation of the ligustrazine hydrochloride liposome and evaluate its quality.METHODS:The liposome was prepared by various methods on a trial basis.The entrapped efficiency(EE)of the liposome derived from passive loading and active loading was compared.RESULTS:The ammonim sulfate gradient technology had the highest EE of 48.63%and its mean size was 6.5?m and the pH was 5.93.It was stable in refrigeratory(4℃～10℃)storage for 30 days.CONCLUSION:The ammonim sulfate gradient technology of preparation of the ligustrazine hydrochloride liposome is feasible.
