Estimating Population Pharmacokinetic Parameters of Verapamil by Iterative Two Stage Method
- VernacularTitle:迭代二步法估算维拉帕米的群体药动学参数
- Author:
Dongya XIA
;
Tao GUO
;
Liping ZHANG
;
Xiaowu YUAN
- Publication Type:Journal Article
- Keywords:
verapamil;
population pharmacokinetics;
iterative two stage method
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide basis for rational use of verapamil in clinical practice.METHODS:53 patients with hypertension received oral verapamil.The concentrations of verapamil in plasma were determined by fluorespectrophotometry.The population pharmacokinetic parameters were estimated by iterative two stage method and compared with the results estimated by traditional standard two stage method.RESULTS:The population pharmacokinetic parameters in 53 patients were,CL(189.3?59.3)ml/(h?kg),Vd(1.420?0.231)L/kg,T1/2(5.74?190)h,the parameters had no significant difference as compared with the parameters estimated by traditional standard two stage method.CONCLUSION:Iterative two stage method is suitable for estimating population pharmacokinetic parameters,forecasting plasma concentration and optimizing individualized dosage regimen.
