Simultaneous Determination of 2 Components in Compound Ornidazole Suppository by RP-HPLC
- VernacularTitle:反相高效液相色谱法同时测定复方奥硝唑栓中两组分的含量
- Author:
Jisheng CHEN
- Publication Type:Journal Article
- Keywords:
ornidazole;
levofloxacin;
RP-HPLC;
content
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a RP-HPLC method for simultaneously determining 2 components in compound ornidazole suppository.METHODS:The HPLC method was performed on Symmetry C18 column(4.6mm?150mm),a mixture of methanol and 0.01mol/L KH2PO4 as mobile phase,and tinidazole as internal standard.The detection wavelength was set at 305nm,and flow rate was 1.0ml/min.RESULTS:The linear rangs of ornidazole and levofloxacin were 5～80?g/ml(r=0.9 997)and 2.5～40?g/ml(r=0.9 999)respectively.The average recovery(n=5)was (100.65?2.27)%for ornidazole,(98.86?1.28)%for levofloxacin.CONCLUSION:This method is rapid,simple and accurate and can be used for the quality control of compound ornidazole suppository.
