Effect of MMP-9 and MMP inhibitor on severe acute pancreatitis associated with lung injury in rats
- VernacularTitle:MMP-9及其抑制剂对实验性重症急性胰腺炎继发肺损伤的影响
- Author:
Ping CHEN
;
Leheng ZHAN
;
Shiwen WANG
;
Youcheng ZHANG
;
Yuliang WANG
- Publication Type:Journal Article
- Keywords:
PANCREATITIS/compl;
ACUTE DISASES;
LUNG/pathol;
PANCREAS/pathol;
MMP-9
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of MMP-9 on severe acute pancreatitis(SAP) associated with lung injury,and the preventive function of MMP-9 inhibitor (BB-94) in SAP associated with lung injury in rats. Methods SD rats were randomly divided into three groups: Shamed-operated groups (control groups,n=10);SAP groups (n=14);SAP with MMP-9 inhibitor preconditioning groups (BB-94 group,n=15). The samples for test of the wet weigh index of lung,serum amylase level,white cell count,the number of cells and protein in bronchoalveolus lavage fluid,histologic scoring of lung injury and MMP-9 in lung were detected 24 hours after SAP models were set up.Results The parameters mentioned above in SAP group were significant higher than those in controll group and BB-94 group (P
