Effect of octreotide on pancreatic cancer cells transfected with SST 2 gene
- VernacularTitle:奥曲肽对胰腺癌细胞转染SST 2后的作用
- Author:
Zhengren LIU
;
Gaosong WU
;
Zhiyong DU
;
Dayu WANG
;
Renyi QIN
;
Fazu QIU
- Publication Type:Journal Article
- Keywords:
PANCREATIC NEOPLASMS/drug ther;
OCTREOTIDE/ther use;
CELL TRANSFECTION;
RECEPTOR SOMOTOSTATIN
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of octreotide on human pancreatic cancer cells (PC-3) apoptosis after PC-3 transfected with somatostatin receptor type 2 (SST 2) gene. Methods SST 2 was transfected into PC-3 by liposome,the result of transfection was detected by immunohistochemistry. The apoptosis of PC-3 induced by using different dosage of octreotide were detected by MTT assay and flow cytometry. Results The effects of killing PC-3 by different dosage (0.2,0.4 and 0.8?g/ml ) of octreotide in transfected groups were significantly stronger than those in non-transfected groups(P
